A mathematical model for cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells

 Tiwari Krishna ktiwari@ebi.ac.uk EMBL-EBI 2023-06-23T11:07:20Z 2023-06-23T11:07:20Z 2023-06-23T11:07:20Z ktiwari@ebi.ac.uk Tiwari Krishna EMBL-EBI EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p2EpoRpJAK2 EpoRActJAK2 p2EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 CISEqc CISRNA CISTurn CISRNA CISEqc CISTurn Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Eqc SOCS3Inh Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Inh SOCS3Eqc 1 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 STAT5 STAT5ActJAK2 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 SOCS3Eqc SOCS3EqcOE SOCS3Turn SOCS3oe SOCS3oe SOCS3Eqc SOCS3Turn SOCS3EqcOE DeaEpoRJAKActSHP1 EpoRpJAK2 SHP1Act SHP1ActEpoR DeaEpoRJAKActSHP1 EpoRpJAK2 SHP1Act SHP1ActEpoR DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p1EpoRpJAK2 DeaEpoRJAKActSHP1 SHP1Act p1EpoRpJAK2 SHP1ActEpoR DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p12EpoRpJAK2 DeaEpoRJAKActSHP1 SHP1Act p12EpoRpJAK2 SHP1ActEpoR DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p2EpoRpJAK2 DeaEpoRJAKActSHP1 SHP1Act p2EpoRpJAK2 SHP1ActEpoR EpoRpJAK2 SHP1 SHP1ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 SHP1 SHP1ActEpoR EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 STAT5Exp npSTAT5 nuc nuc STAT5Exp npSTAT5 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh 3 EpoRpJAK2 EpoRActJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh EpoRpJAK2 EpoRActJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 CIS CISEqc CISInh SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 STAT5 STAT5ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 2 SOCS3 SOCS3Inh SOCS3Eqc 1 CIS CISInh CISEqc 1 CISRNADelay CISnRNA2 nuc nuc CISnRNA2 CISRNADelay ActD CISRNAEqc CISRNATurn npSTAT5 CISRNAEqc CISRNATurn npSTAT5 ActD 1 STAT5Imp cyt pSTAT5 cyt STAT5Imp pSTAT5 ActD SOCS3Eqc SOCS3Turn cyt npSTAT5 cyt SOCS3Eqc SOCS3Turn npSTAT5 ActD 1 EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p1EpoRpJAK2 3 EpoRActJAK2 p1EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 init_EpoRJAK2 0 0 0 0 init_SHP1 0 init_STAT5 0 0 0 0 0 0 0 epo_level STAT5 pSTAT5 0.275 npSTAT5 pSTAT5 Total_STAT5 100 pSTAT5 Total_STAT5 100 cyt Function_for_v_0 Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Eqc SOCS3Inh cyt Function_for_v_1 DeaEpoRJAKActSHP1 EpoRpJAK2 SHP1Act SHP1ActEpoR cyt Function_for_v_2 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh cyt Function_for_v_3 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh cyt Function_for_v_4 EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p1EpoRpJAK2 cyt Function_for_v_5 EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p2EpoRpJAK2 cyt Function_for_v_6 DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p1EpoRpJAK2 cyt Function_for_v_7 DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p2EpoRpJAK2 cyt Function_for_v_8 DeaEpoRJAKActSHP1 SHP1Act SHP1ActEpoR p12EpoRpJAK2 cyt Function_for_v_11 EpoRpJAK2 SHP1 SHP1ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 cyt SHP1Dea SHP1Act cyt Function_for_v_13 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 cyt Function_for_v_14 CIS CISEqc CISInh SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 Function_for_v_15 STAT5Imp cyt pSTAT5 Function_for_v_16 STAT5Exp npSTAT5 nuc nuc Function_for_v_17 ActD CISRNAEqc CISRNATurn npSTAT5 nuc CISRNADelay CISnRNA1 Function_for_v_19 CISRNADelay CISnRNA2 nuc cyt CISRNATurn CISRNA cyt Function_for_v_21 CISEqc CISRNA CISTurn cyt CISTurn CIS Function_for_v_23 ActD SOCS3Eqc SOCS3Turn cyt npSTAT5 cyt SOCS3Turn SOCS3 cyt Function_for_v_25 SOCS3Eqc SOCS3EqcOE SOCS3Turn SOCS3oe